Metabolic Encephalopathy (L-2-Hydroxyglutaric Aciduria)
L-2-Hydroxyglutaric aciduria is a deficiency in an enzyme (L-2-hydroxyglutarate dehydrogenase), which causes defects in the catabolism of organic acids, leading to the accumulation of L-2-hydroxyglutarate in cells.
Age of Onset: 6 months - 2 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Altered behavior (hyperactivity, aggression
Dementia
Seizures
Posture and Appearance
Postural defects
Wide-based stance
Movement
Ataxia
Dysmetric gait
Head pressing
Head and neck tremors
Loss of balance
Muscular stiffness
Thoracic limb hypermetria
Truncal sway
Cranial Nerves
Impaired vision
Decreased menace response
Behavioral/Mental Awareness
Altered behavior (hyperactivity, aggression
Dementia
Seizures
Posture and Appearance
Postural defects
Wide-based stance
Movement
Ataxia
Dysmetric gait
Head pressing
Head and neck tremors
Loss of balance
Muscular stiffness
Thoracic limb hypermetria
Truncal sway
Cranial Nerves
Impaired vision
Decreased menace response
DIffuse central nervous system
Autosomal recessive L2HGDH gene mutation
To read more about this disease click below:
