Neuronal Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis are a group of lysosomal storage disorders characterized by intracellular accumulations resulting in progressive neuronal degeneration.
Age of Onset: Adult onset (>4 years of age)
Sex Predisposition: Any sex of dog can be affected
Clinical Course:
Clinical signs slowly progress over time. After years of progression, the dog may be unable to stand or walk.
Clinical signs slowly progress over time. After years of progression, the dog may be unable to stand or walk.
Clinical Signs:
Movement
Ataxia
Head tremors
Tetraparesis
Hypermetria
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response bilaterally
Vertical positional nystagmus
Spinal Reflexes
Hypertonic limbs
Movement
Ataxia
Head tremors
Tetraparesis
Hypermetria
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response bilaterally
Vertical positional nystagmus
Spinal Reflexes
Hypertonic limbs
Intracranial - diffuse
Autosomal recessive TPP1 (CLN2) gene mutation
For breed specific genetic testing, click the link below:
https://www.animalabs.com/shop/dachshund-wire-haired/ncl-2-dachshund-type/
https://embarkvet.com/products/dog-health/health-conditions/neuronal-ceroid-lipofuscinosis-2-ncl-2/
For breed specific genetic testing, click the link below:
https://www.animalabs.com/shop/dachshund-wire-haired/ncl-2-dachshund-type/
https://embarkvet.com/products/dog-health/health-conditions/neuronal-ceroid-lipofuscinosis-2-ncl-2/
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