Neuronal Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis are a group of lysosomal storage disorders characterized by intracellular accumulations resulting in progressive neuronal degeneration.
Age of Onset: 12-16 months of age
Sex Predisposition: Any sex of dog can be affected
Clinical Course:
Clinical signs slowly progress over time. After years of progression, the dog may be unable to stand or walk.
Clinical signs slowly progress over time. After years of progression, the dog may be unable to stand or walk.
Clinical Signs:
Behavioral/Mental Awareness
Seizures
Personality change (anxiety and restlessness)
Aggression
Hyperactivity
Loss of learned behavior
Self-mutilation
Movement
Ataxia
Head tremors
Paresis of the neck and limb muscles
"Swimming movement"
Inability to stand
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Dysphagia
Painful Reactions
Hyperesthesia
Behavioral/Mental Awareness
Seizures
Personality change (anxiety and restlessness)
Aggression
Hyperactivity
Loss of learned behavior
Self-mutilation
Movement
Ataxia
Head tremors
Paresis of the neck and limb muscles
"Swimming movement"
Inability to stand
Proprioception
Proprioceptive deficits
Cranial Nerves
Visual impairment
Dysphagia
Painful Reactions
Hyperesthesia
Diffuse CNS
Autosomal recessive NCL8 gene mutation
For breed specific genetic testing, click the link(s) below:
www.genomia.cz/en/test/ncl8-saluki/
www.thekennelclub.org.uk/health-and-dog-care/health/getting-started-with-health-testing-and-screening/dna-testing/dna-test-sal-ncl/
For breed specific genetic testing, click the link(s) below:
www.genomia.cz/en/test/ncl8-saluki/
www.thekennelclub.org.uk/health-and-dog-care/health/getting-started-with-health-testing-and-screening/dna-testing/dna-test-sal-ncl/
To read more about this disease click below:
