Leukoencephalomyelopathy (LEM)
Leukoencephalopathies are disorders of central nervous system white matter resulting in progressive demyelination.
Age of Onset: 1.5 - 4 years
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs often present acutely and progress over the course of several months
Clinical signs often present acutely and progress over the course of several months
Clinical Signs:
Movement
Ataxia
Generalized weakness
Hypermetric gait in all 4 limbs
Proprioception
Proprioceptive deficits
Spinal Reflexes
Hyperreflexia
Movement
Ataxia
Generalized weakness
Hypermetric gait in all 4 limbs
Proprioception
Proprioceptive deficits
Spinal Reflexes
Hyperreflexia
Diffuse central nervous system
Autosomal recessive NAPEPLD gene mutation
For breed-specific genetic testing, click the link(s) below:
https://canine-genetics.umn.edu/canine-genetic-testing/leukoencephalomyelopathy
https://vgl.ucdavis.edu/test/lemp
For breed-specific genetic testing, click the link(s) below:
https://canine-genetics.umn.edu/canine-genetic-testing/leukoencephalomyelopathy
https://vgl.ucdavis.edu/test/lemp
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