Gangliosidosis Type 1 (GM1)
Gangliosidosis (GM1) is an inherited deficiency in the enzyme beta-galactosidase which causes defects in the catabolism of gangliosides resulting in their accumulation in neuron lysosomes.
Age of Onset: 5-7 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Aggression
Dementia
Seizures
Posture and Appearance
Wide-based stance
Movement
Ataxia
Hypermetria
Head Tremor
Spastic Paraplegia or Tetraplegia
Spinal Reflexes
Hyperreflexia/Normoreflexia
Cranial Nerves
Visual Impairment
Nystagmus
Absent menace response
Other
Death
Behavioral/Mental Awareness
Aggression
Dementia
Seizures
Posture and Appearance
Wide-based stance
Movement
Ataxia
Hypermetria
Head Tremor
Spastic Paraplegia or Tetraplegia
Spinal Reflexes
Hyperreflexia/Normoreflexia
Cranial Nerves
Visual Impairment
Nystagmus
Absent menace response
Other
Death
Diffuse central nervous system
Autosomal recessive GLB1 gene mutation
For breed-specific genetic testing, click the link(s) below:
https://www.genomia.cz/en/test/gm1/
https://www.wisdompanel.com/en-us/dog-health-conditions/gm1-gangliosidosis-portuguese
https://labogen.com/en/genetic-diseases-dog/gm1-gangliosidosis-gm1/
For breed-specific genetic testing, click the link(s) below:
https://www.genomia.cz/en/test/gm1/
https://www.wisdompanel.com/en-us/dog-health-conditions/gm1-gangliosidosis-portuguese
https://labogen.com/en/genetic-diseases-dog/gm1-gangliosidosis-gm1/
To read more about this disease click below:
