Cerebellar Abiotrophy/Cerebellar Cortical Abiotrophy/Cerebellar Cortical Degeneration/Cerebellar Degeneration
Cerebellar abiotrophy results from a loss of vital substance for continued life of the neuron. Many of these diseases are associated with loss of purkinje cells.
Age of Onset: Clinical signs may be present from birth to 4 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically worsen over time
Clinical signs typically worsen over time
Clinical Signs:
Posture and Appearance
Periodic opisthotonus
Wide-base stance
Movement
Hypermetria/Dysmetria
Ataxia
Intention tremor
Inability to stand or maintain balance
Unable to remain in a sternal position
Mild spasticity
“lurching” or forward-falling movements
Loss of muscle tone
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response
Nystagmus
Spinal Reflexes
Exaggerated spinal reflexes
Posture and Appearance
Periodic opisthotonus
Wide-base stance
Movement
Hypermetria/Dysmetria
Ataxia
Intention tremor
Inability to stand or maintain balance
Unable to remain in a sternal position
Mild spasticity
“lurching” or forward-falling movements
Loss of muscle tone
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response
Nystagmus
Spinal Reflexes
Exaggerated spinal reflexes
Cerebellum
Autosomal recessive inheritance of RAB24 gene mutation
For breed specific genetic testing follow the link below:
https://hospital.cvm.ncsu.edu/services/small-animals/genetics/gordon-setter-cerebellar-degeneration/
For breed specific genetic testing follow the link below:
https://hospital.cvm.ncsu.edu/services/small-animals/genetics/gordon-setter-cerebellar-degeneration/
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