Juvenile Paroxysmal Dyskinesia
Dyskinesias are disorders of movement in conscious individuals resulting from dysfunction of the central nervous system. Dyskinesias are characterized by episodic, usually self-limiting, abnormal, and/or involuntary movements.
Age of Onset: 10 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs occur sporadically at variable frequencies and typically progress in frequency and severity over the course of several weeks in this breed
Uniquely, in this breed, episodes occur while the animal is excited or can be elicited by exercise. Each episode can have varying length, ranging from a few minutes to more than 2 hours.
In between episodes, the animal has no other neurologic abnormalities
Clinical signs occur sporadically at variable frequencies and typically progress in frequency and severity over the course of several weeks in this breed
Uniquely, in this breed, episodes occur while the animal is excited or can be elicited by exercise. Each episode can have varying length, ranging from a few minutes to more than 2 hours.
In between episodes, the animal has no other neurologic abnormalities
Clinical Signs:
Behavioral/Mental Awareness
Maintenance of consciousness during episodes
Attention seeking
Posture and Appearance
Hunched back
High-stepping gait
Movement
Tetraparesis
Dystonia (limbs held in full or partial flexion for several seconds)
Choreoathetosis (exaggerated rapid flexion and extension of the limbs)
Muscle fasciculations
Licking and biting movements
Behavioral/Mental Awareness
Maintenance of consciousness during episodes
Attention seeking
Posture and Appearance
Hunched back
High-stepping gait
Movement
Tetraparesis
Dystonia (limbs held in full or partial flexion for several seconds)
Choreoathetosis (exaggerated rapid flexion and extension of the limbs)
Muscle fasciculations
Licking and biting movements
Central nervous system, likely motor coordination/control regions
Autosomal recessive SOD1 gene mutation
For breed-specific genetic testing, click the link(s) below:
https://www.combibreed.com/paroxysmal-dyskinesia-pd-markiesje/
For breed-specific genetic testing, click the link(s) below:
https://www.combibreed.com/paroxysmal-dyskinesia-pd-markiesje/
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