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Metabolic Encephalopathy (Malonic Aciduria)
  • Description
  • Signalment
  • Clinical Features
  • Neurolocalization
  • Genetics
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Malonic aciduria is a result of defects in the catabolism of organic acids leading to the accumulation of malonic acid in cells.
Age of Onset: Less than 6 months of age
Sex Predisposition: Any sex of animal may be affected
Clinical Course:
​Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Abnormal mentation (stupor)
Seizures

Posture and Appearance
Stunted growth

Movement
Decreased tone

Cranial Nerves
Nystagmus
​

Other
Anorexic
Chemistry findings: Metabolic acidosis, hypoglycemia
Urinalysis findings: Ketonuria
Polyuria/polydipsia
Diffuse central nervous system (metabolic)
Unknown
To read more about this disease click below:
References
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