Hereditary Ataxia/Spinocerebellar Ataxia
Hereditary ataxia is a degenerative spinal disease affecting spinal cord white matter, central auditory pathways, and peripheral nerves.
Belgian Malinois dogs have been noted to have a variety of movement disorders diagnosed at a young age. While clinically similar, these disease may present with distinct histopathologic lesions with little overlap in genetic sequencing.
Belgian Malinois dogs have been noted to have a variety of movement disorders diagnosed at a young age. While clinically similar, these disease may present with distinct histopathologic lesions with little overlap in genetic sequencing.
Age of Onset: 2 weeks-6 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs progress for a period of time, then became stable
Clinical signs progress for a period of time, then became stable
Clinical Signs:
Behavioral/Mental Awareness
Abnormal vocalization
Aggression
Anxiety
Excessive facial rubbing
Seizures
Posture and Appearance
Poor growth
Movement
Ataxia
Hypermetria
Intention tremor
Truncal sway
Myotonia
Myokymic-like muscle contractions
Paresis
Prancing/dancing gait
Increased muscle tone
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent/decreased menace response
Spinal Reflexes
Exaggerated spinal reflexes
Behavioral/Mental Awareness
Abnormal vocalization
Aggression
Anxiety
Excessive facial rubbing
Seizures
Posture and Appearance
Poor growth
Movement
Ataxia
Hypermetria
Intention tremor
Truncal sway
Myotonia
Myokymic-like muscle contractions
Paresis
Prancing/dancing gait
Increased muscle tone
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent/decreased menace response
Spinal Reflexes
Exaggerated spinal reflexes
Cerebellum +/- Spinal cord
Autosomal recessive inheritance:
Spinocerebellar Ataxia: SLC12A6 mutation
CNS Atrophy and Cerebellar Ataxia (CACA): SELENOP mutation
Cerebellar Ataxia: RALGAPA1 mutation
For breed specific genetic testing, follow the links below:
SLC12A6 mutation:
https://www.wisdompanel.com/en-us/dog-health-conditions/hereditary-ataxia-malinois
https://www.alphadogdna.com/pages/hereditary-ataxia-belgian-malinois-type?srsltid=AfmBOop5po1FllqroF5VUFTrm8BhyulyTV1nHrIUU650Dpb0zkCwhguA
https://www.alphadogdna.com/pages/hereditary-ataxia-belgian-malinois-type?srsltid=AfmBOop5po1FllqroF5VUFTrm8BhyulyTV1nHrIUU650Dpb0zkCwhguA
RALGAP1 mutation:
https://www.genomia.cz/en/test/ca1/
https://breeding.dog/index.php?test=bsp
Spinocerebellar Ataxia: SLC12A6 mutation
CNS Atrophy and Cerebellar Ataxia (CACA): SELENOP mutation
Cerebellar Ataxia: RALGAPA1 mutation
For breed specific genetic testing, follow the links below:
SLC12A6 mutation:
https://www.wisdompanel.com/en-us/dog-health-conditions/hereditary-ataxia-malinois
https://www.alphadogdna.com/pages/hereditary-ataxia-belgian-malinois-type?srsltid=AfmBOop5po1FllqroF5VUFTrm8BhyulyTV1nHrIUU650Dpb0zkCwhguA
https://www.alphadogdna.com/pages/hereditary-ataxia-belgian-malinois-type?srsltid=AfmBOop5po1FllqroF5VUFTrm8BhyulyTV1nHrIUU650Dpb0zkCwhguA
RALGAP1 mutation:
https://www.genomia.cz/en/test/ca1/
https://breeding.dog/index.php?test=bsp
To read more about this disease click below:
