Lissencephaly
Lissencephaly is a brain malformation characterized by minimal to no gyri and sulci with cortical thickening giving the brain a smooth appearance.
Age of Onset: Less than 4 years old
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Aggression
Deficient or poor learning capabilities
Altered mentation
Seizures
Movement
May see pelvic limb weakness
Proprioception
Mildly decreased postural reactions
Cranial Nerves
Absent or reduced menace response
Incomplete bilateral pupillary light response
Ventromedial strabismus
Visual defects
Behavioral/Mental Awareness
Aggression
Deficient or poor learning capabilities
Altered mentation
Seizures
Movement
May see pelvic limb weakness
Proprioception
Mildly decreased postural reactions
Cranial Nerves
Absent or reduced menace response
Incomplete bilateral pupillary light response
Ventromedial strabismus
Visual defects
Intracranial
Unknown
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