Metabolic Encephalopathy (Methylmalonic and Malonic Aciduria)
Methylmalonic and Malonic Aciduria is a deficiency in several enzymes which causes defects in the catabolism of organic acids leading to the accumulation of malonic acid and methylmalonic acid in cells.
Age of Onset: Less than 6 months of age
Sex Predisposition: Any sex of animal may be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Abnormal mentation
Posture and Appearance
Extensor rigidity in all limbs
Extended neck
Movement
Ataxic
Circling
Dystonia
“Stiffness” in all limbs
Tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Decreased menace response
Decreased oculocephalic reflex
Strabismus
Spinal Reflexes
Decreased withdrawal reflex
Special Reflexes (e.g. cutaneous trunci)
Diminished gag reflex
Muscle Atrophy
Generalized muscle atrophy
Other
Anorexic
Polydypsia/polyuria
Chemistry findings: Metabolic acidosis, hypoglycemia
Urinalysis findings: Ketonuria
Behavioral/Mental Awareness
Abnormal mentation
Posture and Appearance
Extensor rigidity in all limbs
Extended neck
Movement
Ataxic
Circling
Dystonia
“Stiffness” in all limbs
Tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Decreased menace response
Decreased oculocephalic reflex
Strabismus
Spinal Reflexes
Decreased withdrawal reflex
Special Reflexes (e.g. cutaneous trunci)
Diminished gag reflex
Muscle Atrophy
Generalized muscle atrophy
Other
Anorexic
Polydypsia/polyuria
Chemistry findings: Metabolic acidosis, hypoglycemia
Urinalysis findings: Ketonuria
Brain and spinal cord
Unknown
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