Superficial Neocortical Degeneration
Degeneration and necrosis of the superficial layer of the cerebrum has been reported in some young dogs. While cerebrocortical degeneration has been previously described (either alone or in combination with gray matter lesions at other sites), lesions are not typically restricted to one lamina of the neocortex. Disorder of the superficial neocortex is neuropathologically distinct from previously identified degenerative diseases of the nervous system and the causative agent remains unknown.
Age of Onset: Less than 2 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically worsen over time
Clinical signs typically worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Altred mentation
Behavioral changes (confusion, inability to perform learned tasks, aggression)
Partial seizures
Movement
Difficulty getting up and down stairs
Hypermetria
Hyperextension of the forelimbs
Proprioception
Proprioceptive deficits
Cranial Nerves
Central blindness
Loss of hearing
Difficulty prehending
Facial twitching
Painful Reactions
Hyperesthesia
Behavioral/Mental Awareness
Altred mentation
Behavioral changes (confusion, inability to perform learned tasks, aggression)
Partial seizures
Movement
Difficulty getting up and down stairs
Hypermetria
Hyperextension of the forelimbs
Proprioception
Proprioceptive deficits
Cranial Nerves
Central blindness
Loss of hearing
Difficulty prehending
Facial twitching
Painful Reactions
Hyperesthesia
Superficial neocortex
Unknown
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