Cerebellar Abiotrophy/Cerebellar Cortical Abiotrophy/Cerebellar Cortical Degeneration/Cerebellar Degeneration
Cerebellar abiotrophy results from a loss of vital substance for continued life of the neuron. Many of these diseases are associated with loss of purkinje cells.
Age of Onset: Clinical signs may be present from birth to 6 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically worsen over time
Clinical signs typically worsen over time
Clinical Signs:
Posture and Appearance
Periodic opisthotonus
Wide-base stance
Movement
Hypermetria/Dysmetria
Ataxia
Intention tremor
Inability to stand or maintain balance
Unable to remain in a sternal position
Mild spasticity
“lurching” or forward-falling movements
Loss of muscle tone
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response
Nystagmus
Spinal Reflexes
Exaggerated spinal reflexes
Posture and Appearance
Periodic opisthotonus
Wide-base stance
Movement
Hypermetria/Dysmetria
Ataxia
Intention tremor
Inability to stand or maintain balance
Unable to remain in a sternal position
Mild spasticity
“lurching” or forward-falling movements
Loss of muscle tone
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response
Nystagmus
Spinal Reflexes
Exaggerated spinal reflexes
Cerebellum
Suspected autosomal recessive inheritance
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