Methionine Deficiency-Related Myelinopathy (Hound Ataxia)
Methionine Deficiency-Related Myelinopathy is caused by insufficient methionine (an essential amino acid) which is a building block for protein synthesis. The lack of methionine results in degeneration of the white matter in the spinal cord
Age of Onset: 3-6 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs may progress over the course of a few years
Clinical signs may progress over the course of a few years
Clinical Signs:
Movement
Ataxia (pelvic limbs most commonly affected)
Paraparesis
Proprioception
Proprioceptive deficits (pelvic limbs)
Special Reflexes (e.g. cutaneous trunci)
Abnormal panniculus reflex (caudal to the mid-thoracic/rostral lumbar segments)
Movement
Ataxia (pelvic limbs most commonly affected)
Paraparesis
Proprioception
Proprioceptive deficits (pelvic limbs)
Special Reflexes (e.g. cutaneous trunci)
Abnormal panniculus reflex (caudal to the mid-thoracic/rostral lumbar segments)
Spinal cord
Unknown
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