Hypomyelination (Congenital Tremor Syndrome/Dysmyelination)
Hypomyelination syndrome is characterized by failure to generate a normal myelin sheath-axon relationship within the central nervous system.
Other terms for this syndrome include “shaker pup”, “congenital tremor”, “shaker”, and “trembler” syndromes.
Other terms for this syndrome include “shaker pup”, “congenital tremor”, “shaker”, and “trembler” syndromes.
Age of Onset: 2-8 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs often worsen with excitement or stress and disappear with sleep. The tremor and ataxia may remain stagnant or may improve over time, almost completely resolving by a one year of age.
Clinical signs often worsen with excitement or stress and disappear with sleep. The tremor and ataxia may remain stagnant or may improve over time, almost completely resolving by a one year of age.
Clinical Signs:
Posture and Appearance
Wide-based stance
Movement
Generalized muscle tremors
Ataxia
Dysmetria
Intention tremor
"Hopping" gait with the pelvic limbs
Spinal Reflexes
Depressed patellar reflexes
Posture and Appearance
Wide-based stance
Movement
Generalized muscle tremors
Ataxia
Dysmetria
Intention tremor
"Hopping" gait with the pelvic limbs
Spinal Reflexes
Depressed patellar reflexes
Central nervous system (diffuse) – white matter
Unknown
To read more about this disease click below:
