Multiple System Neuronal Degeneration
Multisystem neuronal degeneration is an inherited progressive neurodegenerative disorder of the central nervous system.
Age of Onset: 5-7 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over the course of several months, signs often worsen with exercise
Clinical signs worsen over the course of several months, signs often worsen with exercise
Clinical Signs:
Movement
Progressive paraparesis to tetraparesis
Hypermetria
Intention tremors
Ataxia
Sudden cataplectic episodes (episodes of generalized atonia/hypotonia)
Wide-based stance
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response bilaterally
Head tilt
Spinal Reflexes
Reduced patellar reflexes
Reduced withdrawal reflexes
Increased appendicular muscle tone
Special functions (e.g. respiration; urination)
Fecal incontinence
Urinary incontinence
Movement
Progressive paraparesis to tetraparesis
Hypermetria
Intention tremors
Ataxia
Sudden cataplectic episodes (episodes of generalized atonia/hypotonia)
Wide-based stance
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response bilaterally
Head tilt
Spinal Reflexes
Reduced patellar reflexes
Reduced withdrawal reflexes
Increased appendicular muscle tone
Special functions (e.g. respiration; urination)
Fecal incontinence
Urinary incontinence
Diffuse central nervous system
Unknown
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