Hereditary Ataxia/Spinocerebellar Ataxia
Hereditary ataxia is a degenerative spinal disease affecting spinal cord white matter, central auditory pathways, and peripheral nerves.
Age of Onset: 6-10 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Two clinical presentations have been described. The first is an early onset rapid progressing severe cerebellar ataxia, progressing over the course of 9-13 weeks. A milder form of the disease has a slower rate of progression and milder clinical signs.
Two clinical presentations have been described. The first is an early onset rapid progressing severe cerebellar ataxia, progressing over the course of 9-13 weeks. A milder form of the disease has a slower rate of progression and milder clinical signs.
Clinical Signs:
Movement
Ataxia
Hypermetria
Intention tremor
Paresis
Prancing/dancing gait
Truncal sway
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent/decreased menace response
Spinal Reflexes
Absent patellar reflexes
Movement
Ataxia
Hypermetria
Intention tremor
Paresis
Prancing/dancing gait
Truncal sway
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent/decreased menace response
Spinal Reflexes
Absent patellar reflexes
Cerebellum and spinal cord
Autosomal recessive KCNJ10 gene mutation
For breed specific genetic testing, follow the link below:
www.genomia.cz/en/test/sdca1/
For breed specific genetic testing, follow the link below:
www.genomia.cz/en/test/sdca1/
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