Muscular Dystrophy (Sarcoglycan Deficient; Limb Girdle Muscular Dystrophy)
Muscular dystrophies are examples of degenerative myopathic conditions of both dogs and cats. Sarcoglycan deficient muscular dystrophies occur due to dysfunction of sarcoglycan membrane proteins.
Limb girdle muscular dystrophies are a subset of muscular dystrophies that preferentially affect the voluntary muscles of the shoulder and hip in some animals.
Limb girdle muscular dystrophies are a subset of muscular dystrophies that preferentially affect the voluntary muscles of the shoulder and hip in some animals.
Age of Onset: 2-7 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over the course of a few months
Clinical signs worsen over the course of a few months
Clinical Signs:
Behavioral/Mental Awareness
Lethargy
Movement
Exercise intolerance
Short-strided and stiff gait
Thoracic limb abduction
Special Functions (e.g. respiration; urination)
Ptyalism
Dysphagia
Regurgitation
Trismus
Muscle Atrophy
Generalized muscle atrophy
Tongue hypertrophy
Other
Hiatal hernia (maybe associated with weakness of the diaphragm)
Behavioral/Mental Awareness
Lethargy
Movement
Exercise intolerance
Short-strided and stiff gait
Thoracic limb abduction
Special Functions (e.g. respiration; urination)
Ptyalism
Dysphagia
Regurgitation
Trismus
Muscle Atrophy
Generalized muscle atrophy
Tongue hypertrophy
Other
Hiatal hernia (maybe associated with weakness of the diaphragm)
Diffuse neuromuscular
Autosomal recessive SGCD (Sarcoglycan) gene mutation
For breed specific genetic testing, follow the links below:
https://www.wisdompanel.com/en-us/dog-health-conditions/limb-girdle-boston
https://www.combibreed.com/limb-girdle-muscular-dystrophy-lgmd-1/
For breed specific genetic testing, follow the links below:
https://www.wisdompanel.com/en-us/dog-health-conditions/limb-girdle-boston
https://www.combibreed.com/limb-girdle-muscular-dystrophy-lgmd-1/
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