Hereditary Polyneuropathy/Neuropathy
Hereditary polyneuropathy/neuropathy is an idiopathic degeneration of nerves often characterized by axonal degeneration and hypomyelination.
Age of Onset: 2-7 months of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Movement
Collapse
Progressive paraparesis to tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent palpebral reflex
Spinal Reflexes
Hyporeflexia (reduced patellar, withdrawal, cutaneous trunci, and anal reflexes)
Special Functions (e.g. respiration; urination)
Exercise intolerance
Inspiratory stridor
Megaesophagus
Urinary incontinence (dribbling urine)
Muscle Atrophy
General muscle atrophy
Atrophy of the muscles of mastication
Pain Sensation
Altered cutaneous sensation of the distal limbs
Movement
Collapse
Progressive paraparesis to tetraparesis
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent palpebral reflex
Spinal Reflexes
Hyporeflexia (reduced patellar, withdrawal, cutaneous trunci, and anal reflexes)
Special Functions (e.g. respiration; urination)
Exercise intolerance
Inspiratory stridor
Megaesophagus
Urinary incontinence (dribbling urine)
Muscle Atrophy
General muscle atrophy
Atrophy of the muscles of mastication
Pain Sensation
Altered cutaneous sensation of the distal limbs
Spinal cord
Autosomal recessive mutation in FAM134B gene
For breed specific genetic testing, follow the links below:
https://www.genomia.cz/en/test/sn/
https://avian2.animalgenetics.com/Canine/Genetic_Disease/SN.asp
For breed specific genetic testing, follow the links below:
https://www.genomia.cz/en/test/sn/
https://avian2.animalgenetics.com/Canine/Genetic_Disease/SN.asp
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