Granulomatous Meningoencephalomyelitis (GME)/Primary Reticulosis
An idiopathic inflammatory response characterized by mesenchymal derived cellular infiltration into the white matter of the brain and spinal cord.
Age of Onset: 9 months – 10 years of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs worsen over time
Clinical signs worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Abnormal vocalization
Aggression
Altered mentation
Excitation/Restlessness
Seizures
Sleepiness
Posture and Appearance
Head tilt
Movement
Ataxia
Circling
Paresis
Tremors
Proprioception
Proprioceptive deficits
Cranial Nerves
Blindness
Variable cranial nerve deficits
Reduced/absent menace response
Spinal Reflexes:
Can be normal or increased/decreased depending on the location of the lesion and the degree of spinal cord involvement
Painful Reactions
Pain on palpation of the cervical vertebral column
May have pain on palpation of the vertebral column over the affected area
Behavioral/Mental Awareness
Abnormal vocalization
Aggression
Altered mentation
Excitation/Restlessness
Seizures
Sleepiness
Posture and Appearance
Head tilt
Movement
Ataxia
Circling
Paresis
Tremors
Proprioception
Proprioceptive deficits
Cranial Nerves
Blindness
Variable cranial nerve deficits
Reduced/absent menace response
Spinal Reflexes:
Can be normal or increased/decreased depending on the location of the lesion and the degree of spinal cord involvement
Painful Reactions
Pain on palpation of the cervical vertebral column
May have pain on palpation of the vertebral column over the affected area
Brain and spinal cord
Unknown
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