Cerebellar Disease
Cerebellar Abiotrophy/Degeneration
Cerebellar Abiotrophy/Cerebellar Cortical Abiotrophy/Cerebellar Cortical Degeneration/Cerebellar Degeneration
Cerebellar abiotrophy results from a loss of vital substance for continued life of the neuron. Many of these diseases are associated with loss of purkinje cells.
Age of Onset: First 6 weeks of age
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Clinical signs typically worsen over time
Clinical signs typically worsen over time
Clinical Signs:
Behavioral/Mental Awareness
Incessant crying
Posture and Appearance
Periodic opisthotonus
Movement
Hypermetria
Dysmetria
Inability to stand
Ataxia
Head tremor
Rolling onto the side
Unable to remain in a sternal position
Intention tremor
Mild spasticity
“lurching” or forward-falling movements
Staggering
Falling
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response
Nystagmus
Behavioral/Mental Awareness
Incessant crying
Posture and Appearance
Periodic opisthotonus
Movement
Hypermetria
Dysmetria
Inability to stand
Ataxia
Head tremor
Rolling onto the side
Unable to remain in a sternal position
Intention tremor
Mild spasticity
“lurching” or forward-falling movements
Staggering
Falling
Proprioception
Proprioceptive deficits
Cranial Nerves
Absent menace response
Nystagmus
Cerebellum
Suspected autosomal recessive inheritance
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Cerebellar Hypoplasia
A congenital malformation that is defined by inadequate development of the cerebellum. Causes can range from genetic abnormalities to in-utero infection. Concurrent hydrocephalus and hydranencephaly may also occur. It has been reported in several dogs with no breed predilection.
Age of Onset: Within first few months of life
Sex Predisposition: Any sex of animal can be affected
Clinical Course:
Variable
Variable
Clinical Signs:
Movement
Intention tremors
Ataxia
Hypermetria, more apparent in hindlimbs
Circling
Stumbling
Falling
Rhythmic dorsoventral bobbing of the head and trunk during elevation of the head
Proprioception
Placing, hopping, and righting marked by hypermetria
Poor proprioception
Cranial Nerves
Absent menace response
Nystagmus
Other
May be associated with related vestibular abnormalities
Movement
Intention tremors
Ataxia
Hypermetria, more apparent in hindlimbs
Circling
Stumbling
Falling
Rhythmic dorsoventral bobbing of the head and trunk during elevation of the head
Proprioception
Placing, hopping, and righting marked by hypermetria
Poor proprioception
Cranial Nerves
Absent menace response
Nystagmus
Other
May be associated with related vestibular abnormalities
Cerebellum
Unknown
To read more about this disease click below:
To read more about this disease click below:
